Stem cell transplantation and identification of molecules have been crucial for regenerative processes for scientific projects. Regenerative process helps in treating Central nervous disorders.
Dr. Athanasios K Petridis has instructed us that by “understanding neuronal development and mimicking developmental steps, i.e. trying to induce expression of molecules expressed during neuronal development when injury to central nervous system occurs, could lead to the effect regeneration”. He also conducted many experimental studies at the Memorial Sloan Kettering Cancer Center from 2002-2005 on Polysialic acid (PSA). He described that PSA was over expressed specifically in glial cells after CNS injury in the brain and spinal cord. This PSA rich environment allowed stem cells to move from the CNS to brain areas which have been injured. In spinal cord lesions the PSA rich gliotic scar enabled neuronal processes to grow through the gliotic scar and pass the scar. A huge wall in regeneration of the CNS, namely the gliotic scar was successfully overpassed.
He also states that “PSA is also used by tumor cells” and in fast spreading tumors PSA is highly expressed and it also helps the cells to stay isolated from other cells and to avoid cell-cell interactions which could even lead to a re-differentiation of tumor cells.
Therefore his studies states to explore the degree of PSA expression which enhances the malignant potential of tumors and how the endo N cleavage could delay tumor growth. These results will be very interesting since a future perspective in treatment of PSA rich tumors with endo N could become reality.